Using a protein family specific platform, the GPCR Network
will work closely with the GPCR community
to determine the HIGH RESOLUTION STRUCTURE
AND FUNCTION of GPCRs distributed broadly across the phylogenetic family tree.
The easily accessible and open data will create a dynamic and informative GPCR-Network of value to the entire scientific community.
GPCR Structures:
NEWS:
May 17, 2012
Special issue of Nature highlighting all four opioid receptor crystal structures
kappa_opioid >>
mu_opioid >>
nociceptin >>
delta_opioid >>
March 21, 2012
Publication of kappa-opioid receptor structure - in the journal Nature
READ MORE >>
February 19, 2012
Publication of S1P1 receptor structure - in the journal Science
READ MORE >>
January 19, 2012
Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR - in Science Express
READ MORE >>
January 12, 2012
TiPS review on GPCR structural diversity and modularity,
MORE Info>>
September 23, 2011
GPCR Network announces their Center and Scientific Advisory Board meeting to be held Monday, November 28, 2011
at TSRI.
Wednesday, August 3, 2011 - PSI:Biology GPCR Network structure researchers hold first annual GPCR Network meeting.
June 22, 2011 In an international collaboration with the Iwata laboratory, the human Histamine H1 receptor structure solved with 1st generation antihistamine. For MORE details please see >>
May 12, 2011 New GPCR Network Assessment Opens - ligand selection for opioid receptors, MORE Info>>
March 10, 2011
Agonist bound structure of the A2A adenosine receptor highlights “conformationally selective agonist” published in Science Express. more>>MOVIE>> Conformational morphing trajectory between inactive, antagonist bound (yellow) and active, agonist bound (orange) forms of A2A adenosine receptor. Re: Xu, F., Wu, H., Katritch, V., Han, G.W., Jacobson, K.A., Gao, Z.G., Cherezov, V. and R,C. Stevens.(2011) Structure of an agonist-bound human A2A adenosine receptor. Science Express, March 10, 2011. Movie prepared with ICM-Pro (Molsoft LLC).